Category talk:CDS

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Computerized provider order entry (CPOE) with clinical decision support (CDS) can improve medication safety and reduce medication-related expenditures. To understand the medication-related benefits of CDS within CPOE to improve medication safety, efficiency, and health care quality, the authors reviewed the common categories of medication-related CDS within CPOE. For each category of CDS, the author considered: how does it work? What is the potential benefit? What are the results that document the benefits and/or harms? What are outstanding issues that prevent the benefit of CDS within CPOE? What are future steps that may help the improvement of CDS? For each category of CDS, the authors made recommendations for how the effectiveness of the feature can be optimized and recommendations to healthcare organizations, software vendors, policy makers and researchers for how to advance the delivery of effective medication-related CDS. The authors divided the CDS categories into two-stages-basic and advanced. The basic CDS includes 1. drug-allergy checking; 2. basic dosing guidance; 3. formulary decision support,; 4. duplicate therapy checking; and 5. drug– drug interaction checking. The advanced decision support includes 6. dosing support for renal insufficiency and geriatric patients; 7. guidance for medication-related laboratory testing; 8. drug– disease contraindication checking; 9. drug–pregnancy checking.

I. Drug-Allergy Checking Potential harm to patients can occur if allergy checking is inadequate—either by missing important alerts or by generating so many unimportant alerts, i.e., over-alerting, that clinicians ignore even important alerts. The authors recommended: allowing clinicians contributing to a common allergy database, requiring a coded allergen and coded reaction for allergy documentation, including evidence-based cross-sensitivity checking, including “reverse allergy checking”, improving specificity of alerts and allergy data quality to avoid over-alerting, analyzing the override reasons, require clinician provide coded override reason and encouraging research that may improve the effectiveness of drug-allergy checking.

II. Basic Dosing Guidance for Medications in CPOE

CPOE with CDS can improve medication dosing through offering the clinician a list of patient-appropriate dosing parameters for each specific medication, provision of lists of pre-defined complete order sentences, and reviewing the order (invisible to the user, by algorithm) after obtaining the user’s dosing parameters, and to alert the clinician only when reasonable dosing parameters have been exceeded

III. Formulary Decision Support

Recommendations for making optimal use of formulary decision support include considering CDS for medication substitution, Strong P&T support and good communication, screening recommendations with expert clinicians first, including link to information describing institution-specific guidelines for restricted medications, pharmacists’ review on a frequent periodic basis the ignored formulary alerts, and educating the users on Formulary changes, New FDA safety alerts and medication shortages.

IV. Duplicate Therapy Checking

Recommendations for best duplicate therapy checking practices include customizing duplicate checking to decrease the number of clinically insignificant alerts and firing duplicate alerts selectively V. Drug–Drug Interaction Checking

The limitations of this category are large numbers of clinically insignificant alerts and important messages that are clinically relevant may be buried. Override rates should be monitored to measure the impact of alerts and better user interface may enable better-informed and more appropriate responses.

Advanced medication-related CDS should only be implemented only after basic CDS is in place. VI. Advanced dosing support for renal insufficiency and geriatric patients Recommendations are determining the most effective way to deliver dosing decision support, developing robust dosing knowledge for the general population as well as special populations (pediatrics, geriatrics, oncology, renal impairment), increasing compliance with dosing suggestions. identifying medications that are most likely to be incorrectly dosed and/or have narrow therapeutic windows, better disseminating dosing knowledge broadly, better reconciling when multiple factors are present that may impact on optimal dose. VII. Advanced Guidance for Medication-associated Laboratory Testing CDS related to medication monitoring could be improved by carrying out reviews and primary research, reviewing and updating monitoring intervals whenever new evidence occurs or when specified inter-review intervals elapse, and improving alerting capabilities to detect when patients are overdue for testing and to notify the patient or clinicians appropriately. VIII. Advanced Checking of Drug–Disease Interactions and Contraindications Advanced drug-disease interaction and contraindication alerts can be improved by developing a standardized, comprehensive source of contraindication information, building consensus among healthcare organizations about which contraindications to include in CPOE systems, and developing methods to ensure that all patient “triggering” morbidities for contraindications can be accessed by CPOE systems during ordering sessions. IX. Advanced Drug–Pregnancy Alerting Drug-pregnancy decision support should focus on improved methods and standards for electronic health records to indicate pregnancy or pregnancy related issues and better delineation of when to interrupt the provider with specific alerts. The authors provided recommendation for future work

  • Recommendations to Healthcare Provider Organizations

Healthcare organizations should actively adopt medication-related CDS safeguards. Each organization should have an appropriate organizational structure and personnel for medication-related CDS implementation and also monitor its effectiveness.

  • Recommendations to CPOE Application Vendors

Vendors should be especially attentive to the user interface (UI) for clinical decision support, support the development of more detailed knowledge bases, implement knowledge management tools for their customers’ use, and encourage the research required to improve the quality and breadth of currently available drug information databases.

  • Recommendation to Drug Information Knowledge- base Vendors

Drug information knowledge-base vendors should work with CPOE and pharmacy system vendors to implement knowledge management tools. knowledge-base vendors should try to create clinically meaningful, pragmatic knowledge that can be applied at the point of care.

  • Recommendations to Policy Makers

Policymakers should provide support to create a single national repository of executable medication-related alerting rules.

  • Recommendations to Research Community

There are plenty opportunities in the area of clinical decision support research such as the extent of impact of alerting on clinician behavior and patient outcomes, the optimal way to present alerts to prescribers and can clinicians’ sense of satisfaction with alerts etc.

In summary, the complexities of CDS require multiple stakeholders in the healthcare system (government agencies, knowledge-base and application vendors, healthcare providers, pharmacies, researchers and informaticians) will need to collaborate to make medication use as safe and effective.