Medications requiring dosage adjustments in renal insufficiency
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References
KAISER PERMANENTE:SAFETY IN PRESCRIBING (SIP). Recommendations for dosing and drug alternatives. Dosing Recommendation in renal dysfunction. FEBRUARY 10, 2003 UPDATE.
| Examples of Medications Requiring Dosage Adjustments in Renal Insufficiency | ==|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug | GFR | Dosing recommendation in alert | Potential safety problem listed in alert |
|---|---|---|---|
| Allopurinol | 51-60
10-50 <10 |
200mg per day maximum
150mg per day maximum Do not use |
Liver and hematoligic toxicity.
|
| Co-trimoxazole | 15-30
<15 |
80/400mg twice per day maximum
Do not use |
Crystalluria and kidney stone formation.
|
| Metformin | <10 | Do not use | Lactic acidosis. |
